Forty sites of TRP channel regulation
Abstract Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert…
TRP channels
The TRPV6 Calcium Channel and Its Relationship with Cancer
Abstract Simple Summary: TRPV6 is a highly selective channel for calcium ions and plays an important role in maintaining calcium…
Role of TRP Channels in Metabolism-Related Diseases
Abstract Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human…
Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold
Abstract TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and…
Molecular pharmacology of the onco-TRP channel TRPV6
Abstract TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the…
Role of TRP Channels in Liver-Related Diseases
Abstract The liver plays a crucial role in preserving the homeostasis of an entire organism by metabolizing both endogenous and…
Cannabidiol sensitizes TRPV2 channels to activation by 2-APB
Abstract The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical…
Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses
Abstract The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient China and Egypt.…
TRP channels in COVID-19 disease: Potential targets for prevention and treatment
Abstract Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that…
An Analysis of the Putative CBD Binding Site in the Ionotropic Cannabinoid Receptors
Abstract Cannabinoids have been long studied for their therapeutic properties, particularly for their use in the treatment of pain. As…