An Analysis of the Putative CBD Binding Site in the Ionotropic Cannabinoid Receptors
Abstract Cannabinoids have been long studied for their therapeutic properties, particularly for their use in the treatment of pain. As…
TRP channels
Molecular mechanism of TRPV2 channel modulation by cannabidiol
Abstract Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol…
Diverse TRPV1 responses to cannabinoids
Abstract Cannabinoid compounds are potential analgesics. Users of medicinal Cannabis report efficacy for pain control, clinical studies show that cannabis…
Cannabinoid Ligands Targeting TRP Channels
Abstract Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of…
TRP Channels as Novel Targets for Endogenous Ligands: Focus on Endocannabinoids and Nociceptive Signalling
Abstract Background: Chronic pain is a significant clinical problem and a very complex pathophysiological phenomenon. There is growing evidence that…
Recent advances in the endocrinology of the sebaceous gland
Abstract The sebaceous gland, long considered an evolutionary relic with little-to-no physiological relevance in humans, has emerged in recent decades…
Transient Receptor Potential Channels as Targets for Phytochemicals
Abstract To date, 28 mammalian transient receptor potential (TRP) channels have been cloned and characterized. They are grouped into six…