Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability
Abstract Telomerase activity plays an essential role in tumor growth and varies across cancers, typically classified as low or high…
telomerase
Inhibition of Myeloma Cell Function by Cannabinoid-Enriched Product Associated With Regulation of Telomere and TP53
Abstract Multiple myeloma is a hematological cancer caused by the uncontrolled proliferation of abnormal plasma cells in the bone marrow,…
Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
Abstract Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets,…
Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
Abstract Simple Summary: Promoter mutations of the telomerase reverse transcriptase (TERT) gene have been suggested as an oncogenic event in…
Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
Abstract Objectives: The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance,…
Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes
Abstract Background: Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to…
Telomerase Regulation from Beginning to the End
Abstract The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere…