Comprehensive Analysis of Large-Scale Transcriptomes from Multiple Cancer Types
Abstract Various abnormalities of transcriptional regulation revealed by RNA sequencing (RNA-seq) have been reported in cancers. However, strategies to integrate…
TCGA
Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors
Abstract Context: Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk is currently predicted using clinical…
Therapeutic potential of the human endogenous retroviral envelope protein HEMO: a pan‐cancer analysis
Abstract Human endogenous retroviruses represent approximately 8% of our genome. Most of these sequences are defective except for a few…
Novel Insights into Epigenetic Regulation of IL6 Pathway: In Silico Perspective on Inflammation and Cancer Relationship
Abstract IL-6 pathway is abnormally hyperactivated in several cancers triggering tumor cell growth and immune system inhibition. Along with genomic…
Pan-Cancer Analysis of Atrial-Fibrillation-Related Innate Immunity Gene ANXA4
Abstract Background: Atrial fibrillation (AF) is the most common tachyarrhythmia around the world. Cancer is one of the main causes…
The molecular feature of macrophages in tumor immune microenvironment of glioma patients
Keywords: CDF, cumulative distribution function, CGGA, Chinese Glioma Genome Atlas, CNA, copy number alternations, CNV, copy number variation, CSF-1, colony-stimulating…
Pan-Cancer Survival Classification With Clinicopathological and Targeted Gene Expression Features
Abstract Prognostication for patients with cancer is important for clinical planning and management, but remains challenging given the large number…
Machine Learning Approaches to Classify Primary and Metastatic Cancers Using Tissue of Origin-Based DNA Methylation Profiles
Abstract Simple Summary: Cancer metastasis is considered to be one of the most significant causes of cancer morbidity, accounting for…
Comprehensive Analysis of the Expression Characteristics of the Enhancer of the Zeste Homolog 2 Gene in Pan-Cancer
Abstract Although more and more studies have shown that EZH2 was closely related to human cancer, no pan-cancer analysis is…
The functions and prognostic values of m6A RNA methylation regulators in thyroid carcinoma
Abstract Background: N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression…