Pan-cancer analysis of PDGFRB: Laying the foundation for the development of targeted immunotherapy drugs
Abstract PDGFRB is a type III tyrosine-protein kinase that is abnormally expressed in various cancers and can serve as a…
TCGA
Exploring vimentin expression and its protein interactors across diverse cancer types via the cancer genome atlas datasets: a comprehensive analysis
Abstract Background: The global burden of cancer is escalating, with millions of individuals diagnosed and succumbing to the disease each…
Pan-cancer analysis of the prognosis and immune infiltration of NSUN7 and its potential function in renal clear cell carcinoma
Abstract Background: NSUN7, an enzyme responsible for the RNA m5c modification, has been recognized as a valuable indicator for predicting…
Pan-cancer analysis predicts MBOAT2 as a potential new ferroptosis related gene immune checkpoint
Abstract Background: The phospholipid-modifying enzyme MBOAT2 plays a crucial role in iron homeostasis by inhibiting iron sequestration, thus preventing iron-induced…
Pan-Cancer Characterization Identifies SLC19A1 as an Unfavorable Prognostic Marker and Associates It with Tumor Infiltration Features
Abstract Background: Recent studies have identified solute carrier family 19 member 1 (SLC19A1) as a second messenger transporter that regulates…
Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer
Abstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack…
KLK7 Involvement in Thyroid Papillary Carcinoma Cell Migration and Invasion by EMT via MAPK/ERK Pathways
Abstract Purpose: KLK7, also known as Kallikrein 7, is a secreted enzyme classified as a serine protease. Earlier studies have…
Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC
Abstract We provide a comprehensive picture of the expression landscape of CDC6 in pan-cancer and its close relationship with the…
Pan-Cancer Analysis Identifies YKT6 as a Prognostic and Immunotherapy Biomarker, with an Emphasis on Cervical Cancer
Abstract Background: Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion is crucial for autophagy, making YKT6, a key modulator…
Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological function
Abstract Background: The progestin and adipoQ receptor family member, PAQR11, is recognized for its roles in vesicle trafficking, mitogenic signaling,…