Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration
Abstract Our DNA contains a blueprint for phenotypic traits, which include the immune response to tumors. As cancer immunotherapies continue…
TCGA
A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes
Abstract Background: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies…
Thirty biologically interpretable clusters of transcription factors distinguish cancer type
Abstract Background: Transcription factors are essential regulators of gene expression and play critical roles in development, differentiation, and in many…
Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas
Abstract Background: MUC4 is a membrane-bound mucin that promotes carcinogenetic progression and is often proposed as a promising biomarker for…
Prognostic Value of HMGA2 in Human Cancers: A Meta-Analysis Based on Literatures and TCGA Datasets
Abstract Background: Emerging evidences have shown that the high-mobility group protein A2 (HMGA2) can aberrantly express in human cancers, and…
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types
Abstract Purpose: The aim of this study was to compare and contrast the expression of all members of the Kallikrein…
A comprehensive genomic pan-cancer classification using The Cancer Genome Atlas gene expression data
Abstract Background: The Cancer Genome Atlas (TCGA) has generated comprehensive molecular profiles. We aim to identify a set of genes…
Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes
Abstract The 3 human RAS genes play pivotal roles regulating proliferation, differentiation, and survival in normal cells and become mutated…
Pan-cancer analysis of systematic batch effects on somatic sequence variations
Abstract Background: The Cancer Genome Atlas (TCGA) is a comprehensive database that includes multi-layered cancer genome profiles. Large-scale collection of…
E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle
Abstract Background: Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most…