Transcriptional landscape of human cancers
Abstract The homogeneity and heterogeneity in somatic mutations, copy number alterations and methylation across different cancer types have been extensively…
TCGA
Dissecting the biological relationship between TCGA miRNA and mRNA sequencing data using MMiRNA-Viewer
Abstract Background: MicroRNAs (miRNA) are short nucleotides that interact with their target genes through 3′ untranslated regions (UTRs). The Cancer…
In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy
Abstract Background: Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) Class I molecules bind to peptide fragments of proteins…
Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotype
Abstract Background: The term CpG island methylator phenotype (CIMP) has been used to describe widespread DNA hypermethylation at CpG-rich genomic…
Somatic Mutaome Profile in Human Cancer Tissues
Abstract Somatic mutation is a major cause of cancer progression and varied responses of tumors against anticancer agents. Thus, we…