The Role of Post-Translational Modifications in Necroptosis
Abstract Necroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During…
targeted therapy
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Abstract Sarcopenia is defined as a muscle‐wasting syndrome that occurs with accelerated aging, while cachexia is a severe wasting syndrome…
Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches
Abstract Graphical Abstract: Article type: Review Article Keywords: Skin cancer, Melanoma, Non-melanoma, Etiology, Phytocompounds, Toxicity, Targeted therapy, Combination therapy, Nanotechnology…
Neurofibromatosis: Molecular Pathogenesis and Natural Compounds as Potential Treatments
Abstract The neurofibromatosis syndromes, including NF1, NF2, and schwannomatosis, are tumor suppressor syndromes characterized by multiple nervous system tumors, particularly…
Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer?
Abstract The success of cannabinoids with chronic neuropathic pain and anxiety has been demonstrated in a multitude of studies. With…
Preclinical Advances in Theranostics for the Different Molecular Subtypes of Breast Cancer
Abstract Breast cancer is the most common cancer in women worldwide. The heterogeneity of breast cancer and drug resistance to…
Practical management of adverse events associated with cabozantinib treatment in patients with renal-cell carcinoma
Abstract Cabozantinib is an oral tyrosine-kinase inhibitor whose targets include VEGFR, MET, and AXL. Cabozantinib is approved for the treatment…