Pan‐cancer analysis reveals sex‐specific signatures in the tumor microenvironment
Abstract The processes of cancer initiation, progression, and response to therapy are affected by the sex of cancer patients. Immunotherapy…
Sex differences
Interaction of sex and cannabis in adult in vivo brain imaging studies: A systematic review
Abstract Cannabis has been shown to cause structural and functional neurocognitive changes in heavy users. Cannabis use initiation aligns with…
Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials
Abstract Some evidence suggests that males and females may differ in their responses to acute cannabis effects, including subjective drug…
Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
Abstract There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little…
Differential Cognitive Performance in Females and Males with Regular Cannabis Use
Abstract Objectives: Preclinical and clinical studies suggest that males and females may be differentially affected by cannabis use. This study…
Sex Differences in Tolerance to Delta-9-Tetrahydrocannabinol in Mice With Cisplatin-Evoked Chronic Neuropathic Pain
Abstract Tolerance to the pain-relieving effects of cannabinoids limits the therapeutic potential of these drugs in patients with chronic pain.…
Intravenous self-administration of delta-9-THC in adolescent rats produces long-lasting alterations in behavior and receptor protein expression
Abstract Rationale: Initial exposure to cannabinoids, including Δ-9-tetrahydrocannabinol (THC), often occurs during adolescence. Considerable neurodevelopmental alterations occur throughout adolescence, and…
The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain
Abstract Cannabinoids help in pain treatment through their action on CB1 and CB2 receptors. β-caryophyllene (BCP), an ancient remedy to…
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
Abstract Background: Considering the poorly understood etiology and complex symptoms of chronic neuropathic pain (NP), the lack of effective treatments,…
Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
Abstract The endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its…