The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain
Abstract Cannabinoids help in pain treatment through their action on CB1 and CB2 receptors. β-caryophyllene (BCP), an ancient remedy to…
Sex differences
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
Abstract Background: Considering the poorly understood etiology and complex symptoms of chronic neuropathic pain (NP), the lack of effective treatments,…
Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
Abstract The endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its…
Acute Cannabinoids Produce Robust Anxiety-Like and Locomotor Effects in Mice, but Long-Term Consequences Are Age- and Sex-Dependent
Abstract The rise in cannabinoid legalization and decriminalization in the US has been paired with an increase in adolescents that…
Sex-dependent effects of in utero cannabinoid exposure on cortical function
Abstract Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid signaling during neurodevelopment, causing long-lasting deficits. Despite increasing…
The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences
Abstract Background: Cannabis is the most commonly used illicit drug. In the general population, its use has been linked to…
Marijuana Use, Recent Marijuana Initiation, and Progression to Marijuana Use Disorder Among Young Male and Female Adolescents Aged 12–14 Living in US Households
Abstract Marijuana initiation during adolescence, and early adolescence in particular, is associated with adverse health consequences. Our study used 2005–2014…
Association between cannabis use and methadone maintenance treatment outcomes: an investigation into sex differences
Abstract Background: Cannabis will soon become legalized in Canada, and it is currently unclear how this will impact public health.…
Sex Differences in Cannabis Use and Effects: A Cross-Sectional Survey of Cannabis Users
Abstract Introduction: Despite known sex differences in the endocannabinoid system of animals, little attention has been paid to sex differences…
Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study
Abstract Background: Despite the growing numbers of men and women with opioid use disorder in Canada, sex-specific issues in treatment…