Structural insights into human ABCD3-mediated peroxisomal acyl-CoA translocation
Abstract Human ABC transporters ABCD1–3 are all localized on the peroxisomal membrane and participate in the β-oxidation of fatty acyl-CoAs,…
Protein folding
Robust folding of a de novo designed ideal protein even with most of the core mutated to valine
Abstract De novo designed proteins exhibit a remarkable property of extremely high thermal stability compared with naturally occurring proteins. The…
Engineering protein assemblies with allosteric control via monomer fold-switching
Abstract The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite…
Structural insight into proline cis/trans isomerization of unfolded proteins catalyzed by the trigger factor chaperone
Abstract Molecular chaperones often possess functional modules that are specialized in assisting the formation of specific structural elements, such as…
A molecular mechanism of chaperone-client recognition
Abstract Conformation and dynamics of a chaperone-client interaction at the atomic level show a basic underlying mechanism. Article type: Research…