Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response
Abstract Acquired or innate lack of response to standard HER2-targeted therapies remains a clinical issue in patients with HER2-positive breast…
Predictive markers
Mobile EEG examination of putative biomarkers of mental health in individuals that use cannabis
Abstract Healthy individuals that use cannabis are at greater risk of developing mental health conditions than those that do not…
Blood and urine multi-omics analysis of the impact of e-vaping, smoking, and cessation: from exposome to molecular responses
Abstract Cigarette smoking is a major preventable cause of morbidity and mortality. While quitting smoking is the best option, switching…
Endocannabinoids, endocannabinoid-like compounds and cortisone in head hair of health care workers as markers of stress and resilience during the early COVID-19 pandemic
Abstract The pandemic caused by SARS-CoV-2 impacted health systems globally, creating increased workload and mental stress upon health care workers…
Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records
Abstract Despite the benefits associated with longer buprenorphine treatment duration (i.e., >180 days) (BTD) for opioid use disorder (OUD), retention…
Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use
Abstract Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve…
Identification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging
Abstract The primary cannabinoid in cannabis, Δ9-tetrahydrocannabinol (THC), causes intoxication and impaired function, with implications for traffic, workplace, and other…
Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort
Abstract Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid…
Fear extinction learning and anandamide: an fMRI study in healthy humans
Abstract Anxiety- and trauma-related disorders are severe illnesses with high prevalence. Current treatment options leave room for improvement and the…
Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy
Abstract Autism spectrum disorder (ASD) is a high cost neurodevelopmental condition; and there are currently no effective pharmacological treatments for…