Estimating the predictive power of silent mutations on cancer classification and prognosis
Abstract In recent years it has been shown that silent mutations, in and out of the coding region, can affect…
Predictive markers
Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort
Abstract Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid…
Fear extinction learning and anandamide: an fMRI study in healthy humans
Abstract Anxiety- and trauma-related disorders are severe illnesses with high prevalence. Current treatment options leave room for improvement and the…
Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess…
Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy
Abstract Autism spectrum disorder (ASD) is a high cost neurodevelopmental condition; and there are currently no effective pharmacological treatments for…
A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans
Abstract Cannabis, the most widely used illicit drug, can induce hallucinations. Our understanding of the biology of cannabis-induced hallucinations (Ca-HL)…