Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug
Abstract Medical Cannabis and its major cannabinoids (−)-trans-Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are gaining momentum for various medical purposes as…
Phytocannabinoids
Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities
Abstract Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are primary brain tumors that account…
Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty
Abstract Simple Summary: Neurodegenerative diseases represent an important cause of morbidity and mortality worldwide. Existing therapeutic options are limited and…
Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles
Abstract Antibiotic resistance has become an increasing challenge in the treatment of various infectious diseases, especially those associated with biofilm…
“The Two Sides of the Same Coin”—Medical Cannabis, Cannabinoids and Immunity: Pros and Cons Explained
Abstract Cannabis, as a natural medicinal remedy, has long been used for palliative treatment to alleviate the side effects caused…
Role of Caryophyllane Sesquiterpenes in the Entourage Effect of Felina 32 Hemp Inflorescence Phytocomplex in Triple Negative MDA-MB-468 Breast Cancer Cells
Abstract Cannabis sativa L. crops have been traditionally exploited as sources of fibers, nutrients, and bioactive phytochemicals of medical interest.…
Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
Abstract The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which…
Cannabinoids and Neurogenesis: The Promised Solution for Neurodegeneration?
Abstract The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in…
Pharmacological and Toxicological Effects of Phytocannabinoids and Recreational Synthetic Cannabinoids: Increasing Risk of Public Health
Abstract Synthetic Cannabinoids (CBs) are a novel class of psychoactive substances that have rapidly evolved around the world with the…
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
Abstract Cannabis contains more than 100 phytocannabinoids. Most of these remain poorly characterized, particularly in neurons. We tested a panel…