Abstract Alzheimer’s disease (AD), a complex neurodegenerative disorder, urgently necessitates a multitarget therapeutic approach. This study presents a novel in…
Abstract Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and…
Abstract Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s12640-025-00729-3. Article type: Research Article Keywords: CBD,…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10858-024-00452-9. Article type: Research Article Keywords: Temperature coefficients, Intrinsically…
Abstract (1) Background: Frontotemporal lobar degeneration (FTLD) is a generic term which refers to multiple pathologies, including FTLD-tau. The most…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01534-9. Article type: Research Article Keywords: Parkinson’s disease, Tau…
Abstract A hallmark of Alzheimer’s disease (AD) is the accumulation of tau protein in the brain. Compelling evidence indicates that…
Abstract Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by progressive cognitive impairment. The deposition of amyloid beta…
Abstract Background: Atypical parkinsonian syndromes are rare, fatal neurodegenerative diseases associated with abnormal protein accumulation in the brain. Examples of…
Abstract Tau forms intracellular insoluble aggregates as a neuropathological hallmark of Alzheimer’s disease. Tau is largely unstructured, which complicates the…