Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer
Abstract Background: Cancer remains a leading cause of mortality worldwide, posing a serious threat to public health. The ASPN protein…
Ovarian serous cystadenocarcinoma
The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database
Abstract Objective: To analyze the expression and significance of resistin (RETN) in pan-cancer and determine the prospect of RETN as…
Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer
Abstract Background: Frizzled class receptor 2 (FZD2), is a critical protein in the Wnt signaling pathway, which plays significant roles…
Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis
Abstract Purpose: Interleukin-6 (IL-6) is a central factor linking inflammation to cancer. This study aimed to provide a comprehensive assessment…
Pan-cancer analysis of the prognostic significance and oncogenic role of GXYLT2
Abstract Growing evidence supports an oncogenic role for glucoside xylosyltransferase 2 (GXYLT2) in a number of malignancies. To evaluate the…
Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues
Abstract Endothelial cells (ECs) play an important role in tumor progression. Currently, the main target of anti-angiogenic therapy is the…
Integrative analysis deciphers the heterogeneity of cancer-associated fibroblast and implications on clinical outcomes in ovarian cancers
Keywords: scRNA-seq, Single-cell RNA-sequencing, CAFs, Cancer-associated fibroblasts, HGSOC, High-grade serous ovarian carcinoma, TCGA, The Cancer Genomics Atlas, LUAD, Lung adenocarcinoma,…
Comprehensive analysis of tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2): A potential novel pan-cancer immune checkpoint
Keywords: LAML, Acute Myeloid Leukemia, BLCA, Bladder Urothelial Carcinoma, BRCA, Breast invasive carcinoma, CESC, Cervical squamous cell carcinoma and endocervical…
Comprehensive analysis of the novel omicron receptor AXL in cancers
Keywords: COVID-19, coronavirus disease 2019, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, ACE2, angiotensin-converting enzyme 2, AXL, anexelekto, UMAP, uniform…
Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
Keywords: TME, tumor microenvironment, CAF, cancer-associated fibroblasts, EMT, epithelial-mesenchymal transition, DLBC, diffuse large B-cell lymphoma, TCGA, The Cancer Genome Atlas,…