Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis
Abstract Topoisomerase IIα (TOP2A) plays an oncogenic role in multiple tumor types. However, no pan-cancer analysis about the function and…
oncogenesis
Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study
Abstract The use of Δ8THC is increasing at present across the USA in association with widespread cannabis legalization and the…
Congenital anomaly epidemiological correlates of Δ8THC across USA 2003–16: panel regression and causal inferential study
Abstract Δ8-Tetrahydrocannabinol (Δ8THC) is marketed in many US states as ‘legal weed’. Concerns exist relating to class-wide genotoxic cannabinoid effects.…
Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 2 – categorical bivariate analysis and attributable fractions
Abstract Background: As the cannabis-cancer relationship remains an important open question epidemiological investigation is warranted to calculate key metrics including…
Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 1 – continuous bivariate analysis
Abstract Background: The genotoxic and cancerogenic impacts of population-wide cannabinoid exposure remains an open but highly salient question. The present…
Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 3 – spatiotemporal, multivariable and causal inferential pathfinding and exploratory analyses of prostate and ovarian cancers
Abstract Background : The epidemiology of cannabinoid-related cancerogenesis has not been studied with cutting edge epidemiological techniques. Building on earlier…
Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties
Abstract Background: Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including…
Cannabinoid and substance relationships of European congenital anomaly patterns: a space-time panel regression and causal inferential study
Abstract With reports from Australia, Canada, USA, Hawaii and Colorado documenting a link between cannabis and congenital anomalies (CAs), this…
Genetic fusions favor tumorigenesis through degron loss in oncogenes
Abstract Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in…
Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
Abstract Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins…