Abstract Ever since the ubiquitin proteasome system was characterized, efforts have been made to manipulate its function to abrogate the…
Abstract Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of a…
Abstract Somatic mutation signatures are an informative facet of cancer aetiology, however they are rarely useful for predicting patient outcome.…
Abstract Obesity is a major risk factor for a large number of secondary diseases, including cancer. Specific insights into the…
Abstract Analysis of large gene expression datasets from biopsies of cancer patients can identify co-expression signatures representing particular biomolecular events…
Abstract Glioblastoma (GBM) is the most lethal primary brain tumor with few treatment options. The survival of glioma-initiating cells (GICs)…
Abstract Ars2 is a component of the nuclear cap-binding complex (CBC) that contributes to microRNA biogenesis and is required for…
Abstract RNA Binding Proteins (RBPs) are a class of post-transcriptional regulatory molecules which are increasingly documented to be dysfunctional in…