Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83
Abstract In this study, we investigated the effects of exposition to IC50 dose for 24 h of a new synthetic…
novel synthetic cannabinoids (NSCs)
An outbreak of deaths associated with AMB-FUBINACA in Auckland NZ
Abstract Background: AMB-FUBINACA is a synthetic cannabinoid that has been associated with periodic outbreaks of acute poisonings, but few fatalities.…
Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products
Abstract Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological…
The switch from one substance-of-abuse to another: illicit drug substitution behaviors in a sample of high-risk drug users
Abstract Background: Substitution can be defined as the consciously motivated choice to use one drug, either licit or illicit, instead…
Is adipose tissue suitable for detection of (synthetic) cannabinoids? A comparative study analyzing antemortem and postmortem specimens following pulmonary administration of JWH-210, RCS-4, as well as ∆9-tetrahydrocannabinol to pigs
Abstract Examining fatal poisonings, chronic exposure may be reflected by the concentration in tissues known for long-term storage of drugs.…
hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation
Abstract Phytocannabinoids are psychotropic substances ofcannabis with the ability to bind endocannabinoid (eCB) receptors that regulate synaptic activity in the…
Chronic Use of Synthetic Cannabinoids Is Associated With Impairment in Working Memory and Mental Flexibility
Abstract Background: We have recently shown that chronic use of Synthetic Cannabinoids (SCs) has been associated with mood disorders and…
Personality Traits and Psychotic Proneness Among Chronic Synthetic Cannabinoid Users
Abstract Objective: Chronic use of synthetic cannabinoids (SCs) has been associated with a wide range of negative consequences for health…
Heroin Adulterated with the Novel Synthetic Cannabinoid, 5F-MDMB-PINACA: A Case Series
Abstract Introduction: Heroin can be adulterated with various substances that may or may not have pharmacological effects. Here we report…
A Regulatory Take on Cannabis and Cannabinoids for Medicinal use in the European Union
Abstract The discovery of the endocannabinoid system has raised public interest in the medicinal use of cannabis, phytocannabinoids, and synthetic…