Designer drugs: mechanism of action and adverse effects
Abstract Electronic supplementary material: The online version of this article (10.1007/s00204-020-02693-7) contains supplementary material, which is available to authorized users.…
novel synthetic cannabinoids (NSCs)
Time- and temperature-dependent postmortem concentration changes of the (synthetic) cannabinoids JWH-210, RCS-4, as well as ∆9-tetrahydrocannabinol following pulmonary administration to pigs
Abstract In forensic toxicology, interpretation of postmortem (PM) drug concentrations might be complicated due to the lack of data concerning…
Genotoxic Properties of Synthetic Cannabinoids on TK6 Human Cells by Flow Cytometry
Abstract Novel Psychoactive Substances (NPS) include several classes of substances such as synthetic cannabinoids (SCBs), an emerging alternative to marijuana,…
Abnormal Cannabidiol Affects Production of Pro-Inflammatory Mediators and Astrocyte Wound Closure in Primary Astrocytic-Microglial Cocultures
Abstract Abnormal cannabidiol (abn-CBD) exerts neuroprotective effects in vivo and in vitro. In the present study, we investigated the impact…
Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy
Abstract Cannabis has been used in pain management since 2900 BC. In the 20th century, synthetic cannabinoids began to emerge,…
Cannabinoid1 (CB-1) receptor antagonists: a molecular approach to treating acute cannabinoid overdose
Abstract The legalization of cannabis for both recreational and medical use in the USA has resulted in a dramatic increase…
Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats
Abstract AKB48 is a designer drug belonging to the indazole synthetic cannabinoids class, illegally sold as herbal blend, incense, or…
Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells
Abstract Background: Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have…
A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse
Abstract Drugs of abuse are associated with stroke, especially in young individuals. The major classes of drugs linked to stroke…
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites
Abstract Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but…