The influence of THC:CBD oromucosal spray on driving ability in patients with multiple sclerosis‐related spasticity
Abstract Background: Driving ability is a key function for the majority of patients with multiple sclerosis (MS) to help maintain…
Multiple sclerosis
The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets
Abstract In physiological conditions, different types of macrophages can be found within the central nervous system (CNS), i.e., microglia, meningeal…
Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy
Abstract Background: Multiple sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes variously dominant in different stages…
The role of Sativex in robotic rehabilitation in individuals with multiple sclerosis
Abstract Introduction: Currently, none of the available multiple sclerosis (MS) disease-modifying medications has been shown to stop or reverse gait…
Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges
Abstract It is well known that certain active ingredients of the plants of Cannabis genus, i.e., the “phytocannabinoids” [pCBs; e.g.,…
Medical marijuana for the treatment of vismodegib-related muscle spasm
Keywords: basal cell carcinoma, medical marijuana, muscle cramps, vismodegib, BCC, basal cell carcinoma, CBD, cannabidiol, FDA, US Food and Drug…
An observational postmarketing safety registry of patients in the UK, Germany, and Switzerland who have been prescribed Sativex® (THC:CBD, nabiximols) oromucosal spray
Abstract The global exposure of Sativex® (Δ9-tetrahydrocannabinol [THC]:cannabidiol [CBD], nabiximols) is estimated to be above 45,000 patient-years since it was…
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
Abstract Medicine continues to struggle in its approaches to numerous common subjective pain syndromes that lack objective signs and remain…
Medicinal Cannabis in California: An Interview with Igor Grant, MD
Abstract Dr. Igor Grant, MD, is distinguished professor and chair of psychiatry and director of the HIV Neurobehavioral Research Program…
A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis
Abstract Background: The present study was designed to investigate the efficacy of a new formulation of alone, purified cannabidiol (CBD)…