Diet and disease-related outcomes in multiple sclerosis: A systematic review of clinical trials
Abstract Background: A growing number of clinical trials have investigated the role of diet in multiple sclerosis (MS) patients. We…
Multiple sclerosis
Integrated Management of Multiple Sclerosis Spasticity and Associated Symptoms Using the Spasticity-Plus Syndrome Concept: Results of a Structured Specialists’ Discussion Using the Workmat® Methodology
Abstract Background: Multiple sclerosis (MS) treatment has radically improved over the last years; however, MS symptom management is still challenging.…
The Effect of Cannabis-Based Medicine on Neuropathic Pain and Spasticity in Patients with Multiple Sclerosis and Spinal Cord Injury: Study Protocol of a National Multicenter Double-Blinded, Placebo-Controlled Trial
Abstract Disease or acquired damage to the central nervous system frequently causes disabling spasticity and central neuropathic pain (NP), both…
The Role of B Cells in Primary Progressive Multiple Sclerosis
Abstract The success of ocrelizumab in reducing confirmed disability accumulation in primary progressive multiple sclerosis (PPMS) via CD20-targeted depletion implicates…
Impaired awareness: Why people with multiple sclerosis continue using cannabis despite evidence to the contrary
Abstract Background: With widespread moves toward legalization of cannabis, increasing numbers of people with multiple sclerosis (pwMS) are using the…
Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
Abstract As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic…
Cost-effectiveness of adding Sativex® spray to spasticity care in Belgium: using bootstrapping instead of Monte Carlo simulation for probabilistic sensitivity analyses
Abstract Background: Uncertainty in model-based cost-utility analyses is commonly assessed in a probabilistic sensitivity analysis. Model parameters are implemented as…
Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis
Abstract The modulation of the endocannabinoid system (ECS) has shown positive results in animal models of multiple sclerosis (MS) and…
Immunomodulatory Potential of Cannabidiol in Multiple Sclerosis: a Systematic Review
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s11481-021-09982-7. Article type: Review Article Keywords: Multiple sclerosis, Experimental…
Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity
Abstract Background and Purpose: Cannabidiol (CBD) has been shown to differentially regulate the mechanistic target of rapamycin complex 1 (mTORC1)…