Ontology for Symptomatic Treatment of Multiple Sclerosis
Abstract Objectives: Symptomatic treatment is an essential component in the overall treatment of multiple sclerosis (MS). However, knowledge in this…
Multiple sclerosis
Screening for severe drug-drug interactions in patients with multiple sclerosis: A comparison of three drug interaction databases
Abstract Background: Patients with multiple sclerosis (MS) often undergo complex treatment regimens, resulting in an increased risk of polypharmacy and…
Associated factors of potential drug-drug interactions and drug–food interactions in patients with multiple sclerosis
Abstract Background: Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are…
Correlation of Nabiximols Dose to Steady-State Concentrations of Cannabinoids in Urine Samples from Patients with Multiple Sclerosis
Abstract Therapeutic drug monitoring of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is based on a complex procedure and is therefore not…
A real‐world evidence study of nabiximols in multiple sclerosis patients with resistant spasticity: Analysis in relation to the newly described ‘spasticity‐plus syndrome’
Abstract Background and purpose: Nabiximols is a therapeutic option for patients with multiple sclerosis (MS) spasticity whose symptoms are poorly…
Phytocannabinoids and Cannabis-Based Products as Alternative Pharmacotherapy in Neurodegenerative Diseases: From Hypothesis to Clinical Practice
Abstract Historically, Cannabis is one of the first plants to be domesticated and used in medicine, though only in the…
Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans
Abstract Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the…
Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty
Abstract Simple Summary: Neurodegenerative diseases represent an important cause of morbidity and mortality worldwide. Existing therapeutic options are limited and…
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
Abstract The innate immune response to bacterial and viral molecules involves the coordinated production of cytokines, chemokines, and type I…
Theoretical and Therapeutic Implications of the Spasticity-Plus Syndrome Model in Multiple Sclerosis
Abstract In patients with multiple sclerosis (MS), a typical pattern of muscle tone alteration, known as spasticity, is frequently observed…