New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts
Abstract COVID-19 is caused by the SARS-CoV-2 virus, which enters target cells via interactions with ACE2 and TMPRSS2. Here, we…
Molecular biology
Biomarkers of the Endocannabinoid System in Substance Use Disorders
Abstract Despite substance use disorders (SUD) being one of the leading causes of disability and mortality globally, available therapeutic approaches…
A fluorescence recovery after photobleaching protocol to measure surface diffusion of DAGLα in primary cultured cortical mouse neurons
Abstract This protocol describes using fluorescence recovery after photobleaching (FRAP) of a superecliptic pHluorin (SEP)-diacylglycerol lipase α (DAGLα) to measure…
UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol
Abstract UV radiation is known to induce a multiple changes in the metabolism of skin-building cells, what can affect the…
Development and validation of a real-time PCR assay to detect Cannabis sativa in food
Abstract Regarding the prospective investigation of food authenticity and adulteration the aim of the present study was the development and…
Cannabinoids and Cannabinoid Receptors: The Story so Far
Abstract Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case,…
A General Introduction to Glucocorticoid Biology
Abstract Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their…