Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer
Abstract Liver hepatocellular carcinoma (LIHC) is the major form of liver cancer that is the fourth most common cause of…
LIHC
Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
Keywords: TME, tumor microenvironment, CAF, cancer-associated fibroblasts, EMT, epithelial-mesenchymal transition, DLBC, diffuse large B-cell lymphoma, TCGA, The Cancer Genome Atlas,…
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers
Keywords: AUC, area under the curve, CCLE, cancer cell line encyclopedia, HR, hazard ratio, ROC, receiver operating characteristic, SHCBP1, Shc…
Violations of proportional hazard assumption in Cox regression model of transcriptomic data in TCGA pan-cancer cohorts
Keywords: CPH, Cox proportional hazard regression, PH, proportional hazard, TCGA, The Cancer Genome Atlas, OS, overall survival, GEO, Gene Expression…
Protein profiling reveals potential isomiR-associated cross-talks among RNAs in cholangiocarcinoma
Keywords: BLCA, bladder urothelial carcinoma, BRCA, breast invasive carcinoma, CHOL, cholangiocarcinoma, COAD, colon adenocarcinoma, ESCA, esophageal carcinoma, HNSC, head and…
The molecular feature of macrophages in tumor immune microenvironment of glioma patients
Keywords: CDF, cumulative distribution function, CGGA, Chinese Glioma Genome Atlas, CNA, copy number alternations, CNV, copy number variation, CSF-1, colony-stimulating…
A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy
Abstract Background: The prevalence of HER2 alterations in pan-cancer indicates a broader range of application of HER2-targeted therapies; however, biomarkers…
Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis
Keywords: ACC, adrenocortical carcinoma, BLCA, bladder urothelial carcinoma, BRCA, breast invasive carcinoma, CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma,…
Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer
Keywords: ACC, adrenocortical carcinoma, BLCA, bladder urothelial carcinoma, BRCA, breast invasive carcinoma, CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma,…
PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer
Keywords: Cancer, Microsatellite instability, Gene expression profiling, Machine learning, Algorithm, Classification, AUC, area under the curve, CV, cross validation, GEO,…