Inflammation in cancer: therapeutic opportunities from new insights
Abstract As one part of the innate immune response to external stimuli, chronic inflammation increases the risk of various cancers,…
inflammasome
Full‐spectrum cannabidiol reduces UVB damage through the inhibition of TGF‐β1 and the NLRP3 inflammasome
Abstract The thermodynamic characteristics, antioxidant potential, and photoprotective benefits of full‐spectrum cannabidiol (FS‐CBD) against UVB‐induced cellular death were examined in…
Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders
Abstract During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of…
Anti-inflammatory effects of CBD in human microglial cell line infected with HIV-1
Abstract Human immunodeficiency virus (HIV) infection is associated with a chronic inflammatory stage and continuous activation of inflammasome pathway. We…
The impact of cannabinoids on inflammasome signaling in HIV-1 infection
Abstract Human immunodeficiency virus type 1 (HIV-1) is a chronic disease that afflicts over 38 million people worldwide without a…
Chemical constituents of industrial hemp roots and their anti-inflammatory activities
Abstract Objective: Although the chemical constituents of the aerial parts of Cannabis have been extensively studied, phytochemicals of Cannabis roots…
Hemp Protein Hydrolysates Modulate Inflammasome-Related Genes in Microglial Cells
Abstract Simple Summary: Neuroinflammation can lead to the development of neurodegenerative diseases. Food-derived peptides released by the action of enzymes…
NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation
Abstract In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing…
Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective
Abstract Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes,…
Cannabidiol as a Novel Therapeutic for Immune Modulation
Abstract The immune-suppressive effects of cannabidiol (CBD) are attributed to the modulation of essential immunological signaling pathways and receptors. Mechanistic…