A pan-cancer analysis of the prognostic and immunological roles of zinc finger protein 514 in human tumors
Abstract Background: Recent studies have highlighted the essential role of the zinc finger gene family, whose encoded proteins play a…
immune infiltration
Comprehensive analysis of SELPLG as a potential immunotherapy target and prognostic biomarker in oncology
Abstract Background: SELPLG, which encodes P-selectin glycoprotein ligand-1, has emerged as a potential oncological target. A comprehensive understanding of its…
Targeting NLRC4 for potential therapeutic strategies in lung adenocarcinoma
Abstract Background: Autophagy, a vital cellular process, plays a significant role in the development of a spectrum of diseases, notably…
CLEC3B as a Prognostic and Immunological Biomarker in Pan-Cancer: Multi-Omics Profiling and Validation in Pancreatic Cancer and Exosomes
Abstract Background: Despite the emergence of in vitro and in vivo experiments validating the connection between CLEC3B and various cancers,…
Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer
Abstract Background: Frizzled class receptor 2 (FZD2), is a critical protein in the Wnt signaling pathway, which plays significant roles…
Pan-Cancer Analysis Identifies a Ras-Related GTPase as a Potential Modulator of Cancer
Abstract Ras signaling regulates many cellular processes in cancer development. While well-known Ras-related oncogenes, such as KRAS, have been extensively…
Comprehensive pan-cancer analysis identified SLC16A3 as a potential prognostic and diagnostic biomarker
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12935-025-03791-1. Article type: Research Article Keywords: SLC16A3, Pan-cancer, Prognosis,…
The role and function validation of P2RX4 as a novel cancer biomarker in pan-cancer analysis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-95247-9. Article type: Research Article Keywords: Biomarker, P2RX4, Immune…
Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer
Abstract Background: Schlafen11 (SLFN11) is a key gene in p53-independent apoptosis through ribosome stalling; however, systematic research has been conducted…
Prognostic and Immunological Significance of NMNAT1 in Colorectal and Pan-Cancer Contexts
Abstract Introduction: Nicotinamide plays a critical role in the prevention and treatment of tumors, and its metabolism is closely associated…