Abstract Purpose: RNF213 encodes one of the largest E3 ubiquitin ligases in the human proteome, playing essential roles in ubiquitination,…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-74808-4. Article type: Research Article Keywords: LAG3, Immune checkpoint,…
Abstract Objection: The aim of this work is to screen the immune-related genes to predict the prognosis and provide a…
Abstract Induction of immunoproteasome (IP) expression in tumour cells can enhance antigen presentation and immunogenicity. Recently, the overexpression of IP…
Abstract Metabolic reprogramming is one of the cancer hallmarks, important for the survival of malignant cells. We investigated the prognostic…
Keywords: TME, tumor microenvironment, CAF, cancer-associated fibroblasts, EMT, epithelial-mesenchymal transition, DLBC, diffuse large B-cell lymphoma, TCGA, The Cancer Genome Atlas,…
Abstract Background: The majority of drug-resistant cells in Thyroid cancer (THCA) tend to exhibit an Epithelial mesenchymal transition (EMT) phenotype,…
Abstract The interaction of immune checkpoint molecules in the tumor microenvironment reduces the anti-tumor immune response by suppressing the recognition…
Abstract There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in…
Abstract Non-small cell lung cancer (NSCLC) is the predominant subtype of lung cancers. KRAS mutation is the second most prevalent…