Prognostic value of TMEM59L and its genomic and immunological characteristics in cancer
Abstract Background: TMEM59L is a newly discovered transmembrane protein; its functions in cancer remain unknown. This study was designed to…
immune cells within the tumor microenvironment
Pan-cancer analysis of ASB3 and the potential clinical implications for immune microenvironment of glioblastoma multiforme
Abstract Background: Ankyrin repeat and SOCS Box containing 3 (ASB3) is an E3 ubiquitin ligase. It has been reported to…
Infiltration of LPAR5+ macrophages in osteosarcoma tumor microenvironment predicts better outcomes
Abstract Introduction: Tumor microenvironment (TME) has been shown to be extensively involved in tumor development. However, the dynamic change of…
Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
Abstract Imbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a…
A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors
Abstract Background: Recent studies have identified ribonucleotide reductase subunit M2 (RRM2) as a putative promoter of tumors. However, no systematic…
Comprehensive analysis of the expression profile and clinical implications of regulator of chromosome condensation 2 in pan-cancers
Abstract The Regulator of Chromosome Condensation 2 (RCC2) is an important gene that regulates mitosis and cytoplasmic division in the…
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers
Abstract Background: Trophinin-associated protein (TROAP), a cytoplasmic protein, is essential for microtubule cytoskeleton assembly. Mounting evidence demonstrates the vital role…
Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation
Abstract Introduction: The migrasome is a newly discovered organelle that resembles extracellular vesicles in structure. However, the function of the…
LPCAT1 acts as an independent prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma
Abstract Background: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is overexpressed in multiple human tumors. However, the role of LPCAT1 in hepatocellular carcinoma…
Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer
Abstract Background: Cuproptosis, a copper-dependent controlled cell death, is a novel form of cell death that differs from known cell…