Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer
Abstract Background: Cuproptosis, a copper-dependent controlled cell death, is a novel form of cell death that differs from known cell…
immune cells within the tumor microenvironment
An asparagine metabolism-based classification reveals the metabolic and immune heterogeneity of hepatocellular carcinoma
Abstract Introduction and objectives: hepatocellular carcinoma (HCC) is the major form of liver cancer with a poor prognosis. Amino acid…
KRAS is a prognostic biomarker associated with diagnosis and treatment in multiple cancers
Abstract KRAS encodes K-Ras proteins, which take part in the MAPK pathway. The expression level of KRAS is high in…
Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation
Abstract Background: The absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and…
A pan-cancer analysis of collagen VI family on prognosis, tumor microenvironment, and its potential therapeutic effect
Abstract Background: Collagen VI family (COL6A) is a major member of extracellular matrix protein. There is accumulating evidence that COL6A…
A pan-cancer analysis of the expression of STAT family genes in tumors and their relationship to the tumor microenvironment
Abstract Background: The signal transducer and activator of transcription (STAT) protein family, a group of seven members (STAT1, STAT2, STAT3,…
Pan-cancer analysis of forkhead box Q1 as a potential prognostic and immunological biomarker
Abstract Forkhead box Q1 (FOXQ1) is a member of the forkhead transcription factor family involved in the occurrence and development…
Comprehensive prognostic and immunological analysis of CCT2 in pan-cancer
Abstract CCT2 acts as a molecular chaperone protein that assists in the proper folding of proteins, thus ensuring a dynamic…
Pan-cancer analysis identifies YTHDF2 as an immunotherapeutic and prognostic biomarker
Abstract Background: N6-methyladenosine (m6A) modification is a dynamic and reversible post-transcriptional RNA modification prevalent in eukaryotic cells. YT521-B homology domain…
Identification and validation of an anoikis-associated gene signature to predict clinical character, stemness, IDH mutation, and immune filtration in glioblastoma
Abstract Background: Glioblastoma (GBM) is the most prominent and aggressive primary brain tumor in adults. Anoikis is a specific form…