Single‐Cell and Multiomics Characterization of p21 in Cancer Progression and Therapeutic Sensitivity
Abstract Introduction: CDKN1A (encoding p21) is a canonical regulator of cell cycle arrest and genomic stability. However, its functional spectrum…
immune cells within the tumor microenvironment
Single-cell reveals age-dependent epithelial reprogramming and EMT vulnerability in THCA
Abstract Thyroid cancer exhibits pronounced cellular heterogeneity, yet the mechanisms underlying epithelial–mesenchymal transition (EMT) and tumor microenvironment (TME) remodeling remain…
Pan-Cancer Prognostic Analysis of NMDAR Genes Discovered Therapeutic Implications of Neuronal–Cancer Crosstalk Mediator GRIN2A for Small Cell Lung Cancer
Abstract Background: As the most lethal neuroendocrine tumor, small cell lung cancer (SCLC) can drive its progression by hijacking neuronal…
The retinol-metabolizing enzyme DHRS3 coordinates antigen presentation, endothelial stability, and cholesterol metabolism to suppress hepatocellular carcinoma progression
Abstract Hepatocellular carcinoma (HCC) remains a therapeutic challenge due to tumor microenvironment heterogeneity and metabolic reprogramming. Short-chain dehydrogenase/reductase 3, DHRS3,…
Integrative single-cell and spatial multi-Omics analyses identify NETs-driven colon cancer subtypes with distinct metabolic features and prognostic implications
Abstract Background: Colon cancer remains one of the leading causes of cancer-related deaths worldwide and is associated with high rates…
Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers
Abstract Background: CYP19A1, which encodes the enzyme aromatase necessary for estrogen production, is known to be involved in hormone-sensitive cancers,…
BANF1 as a potential prognostic biomarker associated with tumor-intrinsic programs and a complex immune landscape in lung adenocarcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-026-04992-4. Article type: Research Article Keywords: BANF1, Lung adenocarcinoma,…
Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation
Abstract Glioblastoma (GBM) remains one of the most lethal brain tumors, with current therapies offering limited benefits and high relapse…
Lipid Metabolism Reprogramming in Cancer: Insights into Tumor Cells and Immune Cells Within the Tumor Microenvironment
Abstract This review delves into the characteristics of lipid metabolism reprogramming in cancer cells and immune cells within the tumor…
Cannabinoids and the endocannabinoid system in immunotherapy: helpful or harmful?
Abstract Numerous studies in various cancer models have demonstrated that ingredients of cannabis can influence tumor growth through the endocannabinoid…