Glucocerebrosidase mutations in primary parkinsonism
Abstract Introduction: Mutations in the lysosomal glucocerebrosidase (GBA) gene increase the risk of Parkinson’s Disease (PD). We determined the frequency…
idiopathic Parkinson's disease
The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders
Abstract Objective: Differentiating idiopathic Parkinson’s disease from atypical parkinsonian syndromes is challenging, especially in the early stages. We assessed whether…
Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats
Abstract Rationale: It is known that dopaminergic cell loss leads to increased endogenous cannabinoid levels and CB1 receptor density. Objective:…
Clinical Implications of Cardiac-MIBG SPECT in the Differentiation of Parkinsonian Syndromes
Abstract Background and Purpose: 123I cardiac meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used to estimate myocardial sympathetic nerve…