Cannabidiol modulation of hippocampal glutamate in early psychosis
Abstract Background: Emerging evidence supports the antipsychotic effect of cannabidiol, a non-intoxicating component of cannabis, in people with psychosis. Preclinical…
hippocampus
Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia
Abstract For a better translation from treatment designs of schizophrenia to clinical efficiency, there is a crucial need to refine…
Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy
Abstract Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic effects through the activation of 5-HT1A receptors. These receptors…
The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study
Abstract Background: Cannabidiol (CBD) is being investigated as a potential treatment for several medical indications, many of which are characterised…
The Pro-neurogenic Effects of Cannabidiol and Its Potential Therapeutic Implications in Psychiatric Disorders
Abstract During the last decades, researchers have investigated the functional relevance of adult hippocampal neurogenesis in normal brain function as…
Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
Abstract Different studies have demonstrated that inflammation and alterations in glutamate neurotransmission are two events contributing to the pathophysiology of…
Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Δ9-THC and Ethanol Binge Drinking During Adolescence
Abstract Oleoylethanolamide is an endogenous NAE that modulates ethanol-seeking behavior and ethanol-induced neuroinflammation. In the present study we further analyze…
Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics
Abstract Gene-targeted mice with deficient AMPA receptor GluA1 subunits (Gria1-/- mice) show robust hyperlocomotion in a novel environment, suggesting them…
Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use
Abstract Background and Aims: Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise…
Long-Term Stress and Concomitant Marijuana Smoke Exposure Affect Physiology, Behavior and Adult Hippocampal Neurogenesis
Abstract Marijuana is a widely used recreational drug with increasing legalization worldwide for medical purposes. Most experimental studies use either…