Longitudinal study of hippocampal volumes in heavy cannabis users
Abstract Background: Cannabis exposure, particularly heavy cannabis use, has been associated with neuroanatomical alterations in regions rich with cannabinoid receptors…
hippocampus
Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences
Abstract Fractality, represented as self-similar repeating patterns, is ubiquitous in nature and the brain. Dynamic patterns of hippocampal spike trains…
Increasing Endocannabinoid Levels in the Ventral Pallidum Restore Aberrant Dopamine Neuron Activity in the Subchronic PCP Rodent Model of Schizophrenia
Abstract Background: Schizophrenia is a debilitating disorder that affects 1% of the US population. While the exogenous administration of cannabinoids…
Genes and signaling pathways involved in memory enhancement in mutant mice
Abstract Mutant mice have been used successfully as a tool for investigating the mechanisms of memory at multiple levels, from…
Caudate nucleus-dependent navigational strategies are associated with increased use of addictive drugs
Abstract This study aimed to investigate the relationship between navigational strategies and the use of abused substances in a sample…
Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice
Abstract Neuregulin 1 (NRG1) is linked to an increased risk of developing schizophrenia and cannabis dependence. Mice that are hypomorphic…
Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia
Abstract Clinical studies report associations between cannabis use during adolescence and later onset of schizophrenia. We examined the causal relationship…
The Role of Cannabinoids in Modulating Emotional and Non-Emotional Memory Processes in the Hippocampus
Abstract Cannabinoid agonists generally have a disruptive effect on memory, learning, and operant behavior that is considered to be hippocampus-dependent.…
Hippocampal CB1 receptors mediate the memory impairing effects of Δ9-tetrahydrocannabinol
Abstract It is firmly established that the hippocampus, a brain region implicated in spatial learning, episodic memory, and consolidation, contains…