Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats
Abstract The study aimed to explore in vivo the influence of cannabidiol (CBD) on the development of alcohol tolerance in…
hippocampus
Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice
Abstract Endocannabinoid system activity declines with age in the hippocampus, along with the density of the cannabinoid receptor type-1 (CB1).…
Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice
Abstract JWH-073 is a synthetic cannabinoid (SCB) that is illegally marketed within an “herbal blend”, causing psychoactive effects more intense…
Cannabidiol Modulating the Expression of Neurotrophin Signaling Pathways in Chronic Exposure to Methamphetamine in Rats During Abstinence Period
Abstract Introduction: Several neuropsychiatric disorders, such as addiction, have indicated variations in the levels of neurotrophic factors. As an extremely…
Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits
Abstract Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing…
Behavioral and Molecular Responses to Exogenous Cannabinoids During Pentylenetetrazol-Induced Convulsions in Male and Female Rats
Abstract Epilepsy is a disabling, chronic brain disease,affecting ~1% of the World’s population, characterized by recurrent seizures (sudden, uncontrolled brain…
Cannabidiol activates neuronal Kv7 channels
Abstract Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective antiepileptic drug whose mechanism of…
Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents
Abstract There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little…
Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity
Abstract Increasing evidence supports a link between maternal prenatal cannabis use and altered neural and physiological development of the child.…
Regulation of stress-provoked aggressive behavior using endocannabinoids
Abstract Reactive impulsive aggression is characterized by outbursts of rage and violence when subjects encounter threatening stressful events. Although impulsive…