Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice
Abstract Aging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently,…
hippocampus
A rare cause of acute hippocampal encephalopathy
Abstract Hippocampal encephalitis (HE), or more generally limbic encephalitis, can be secondary to various etiologies. Through this case, we report…
Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus
Abstract Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the…
The effect of traumatic brain injury on learning and memory: A synaptic focus
Abstract Deficits in learning and memory are some of the most commonly reported symptoms following a traumatic brain injury (TBI).…
A combination of Δ9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer’s disease
Abstract A combination of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) at non-psychoactive doses was previously demonstrated to reduce cognitive decline in…
Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
Abstract Post-traumatic stress disorder (PTSD) is the most common psychiatric disorder after a catastrophic event; however, the efficacious treatment options…
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene…
Acute toxic hippocampal encephalopathy in heavy cannabis users: A case report
Abstract Cannabis use is increasing rapidly among young people worldwide despite the deleterious effects of this toxic substance on health.…
Coping with the multifaceted and multifunctional role of cortisol in the brain
Abstract Glucocorticoid hormones cortisol and corticosterone (collectively called CORT), secreted as the end products of the hypothalamus-pituitary-adrenal (HPA)-axis, coordinate body…
Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders
Abstract Fear refers to an adaptive response in the face of danger, and the formed fear memory acts as a…