Astrocytic GPR55 receptors promote glycolysis
Abstract Background: The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that…
hippocampus
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
Abstract Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic,…
Involvement of Adenosine A2A Receptors in Anxiety‐Like Behaviors in Tetrahydrocannabinol‐Treated Mice
Abstract Background: Previous studies have suggested that adenosinergic system in the central nervous system may play a role in both…
The CB1 receptor: linking impulsivity and substance use disorder
Abstract The cannabinoid receptor type 1 (CB1R) is the most widely expressed G protein-coupled receptor in the brain, with high…
Cannabidiol reverses depression-like behaviors by enhancing hippocampal synaptic plasticity in rats with chronic restraint stress
Abstract Background and Aim: Major depressive disorder is a prevalent psychiatric condition associated with impaired neuroplasticity, particularly in the hippocampus.…
Cannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition
Abstract Cannabidiol (CBD) decreases seizures in patients with severe pediatric-onset epilepsies including Dravet, Lennox-Gastaut, and Tuberous Sclerosis syndromes. However, the…
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington’s disease models
Abstract Background: Dysregulation of the endocannabinoid system (eCBS) and the loss of CB1 receptors (CB1R) in the basal ganglia are…
Large-Scale Profiling of Coding and Long Noncoding Transcriptomes in the Hippocampus of Mice Acutely Exposed to Vaporized CBD or THC
Abstract Cannabis vaping, particularly involving cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), rapidly delivers highly concentrated cannabinoids to the brain, potentially affecting…
Synaptic signatures of perinatal cannabinoids: A systematic review of rodent hippocampal synaptic plasticity, learning, and memory
Abstract The expanding legalization of cannabis raises significant public health concerns about its use during pregnancy, particularly due to the…
Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
Abstract Background: Recent preclinical studies have shown sex-dependent antidepressant-like responses of cannabidiol in adolescence, which were dependent on biological sex,…