Abstract This review aims at highlighting the interplay between the endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol and sphingosine-1-phosphate (S1P) signaling. The…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00262-024-03801-7. Article type: Review Article Keywords: GPCRs, Immune checkpoint…
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
Abstract The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis…
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
Abstract Effective treatments for pain management remain elusive due to the dangerous side-effects of current gold-standard opioid analgesics, including the…
Abstract The endocannabinoid system (ECS) has been shown to be of great importance in the regulation of numerous physiological and…
Abstract Drug abuse (DA) and addiction is a complex illness, broadly viewed as a neurobiological impairment with genetic and environmental…