Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-04135-1. Article type: Research Article Keywords: p62/SQSTM1, Immune cell…
Abstract In the United States, Black individuals have higher rates of cancer mortality than any other racial group. Here, we…
Abstract DNA damage repair (DDR) is critical in maintaining normal cellular function and genome integrity and is associated with cancer…
Abstract Background: Intratumor heterogeneity (ITH) is associated with tumor progression, unfavorable prognosis, immunosuppression, genomic instability, and therapeutic resistance. Thus, evaluation…
Abstract Tumor cells show widespread genetic alterations that change the expression of genes driving tumor progression, including genes that maintain…
Keywords: Spliceosome pathway, Pan-cancer, Anti-tumor immunity, Cancer immunotherapy, Drug response, Genomic instability Authors: Zuobing Chen, Canping Chen, Lin Li, Tianfang…
Abstract Background: Maintaining a proper supply of soluble histones throughout the cell cycle is important to ensure chromatin and genome…
Abstract Intratumor genetic heterogeneity (ITH) is the main obstacle to effective cancer treatment and a major mechanism of drug resistance.…