Dural lymphatics regulate clearance of extracellular tau from the CNS
Abstract Background: Alzheimer’s disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates…
Genetic tauopathy
Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant
Abstract Electronic supplementary material: The online version of this article (10.1186/s40478-019-0661-2) contains supplementary material, which is available to authorized users.…
Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies
Abstract Electronic supplementary material: The online version of this article (doi:10.1186/s40478-016-0406-4) contains supplementary material, which is available to authorized users.…
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Abstract Introduction: The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases.…