Peroxisomes, PPARs, and Their Role in Macrophages
Abstract Macrophages are versatile immune cells capable of modifying their functions based on their location and the specific requirements of…
Gene regulation in immune cells
Cannabidiol as an immune modulator: A comprehensive review
Abstract Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has emerged as a promising therapeutic agent due to its…
Interplay between cannabinoids and the neuroimmune system in migraine
Abstract Migraine is a common and complex neurological disorder that has a high impact on quality of life. Recent advances…
Inflammation and cancer: friend or foe?
Abstract Chronic inflammation plays a crucial role in the onset and progression of pathologies like neurodegenerative and cardiovascular diseases, diabetes,…
TRP Ion Channels in Immune Cells and Their Implications for Inflammation
Abstract The transient receptor potential (TRP) ion channels act as cellular sensors and mediate a plethora of physiological processes, including…
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Abstract Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic…
Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer
Abstract Background: The origin recognition complex 1 (ORC1) is a large subunit of the origin recognition complex and acts as…
Inflammation—the role of TRPA1 channel
Abstract Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a…
TRPA1 Role in Inflammatory Disorders: What Is Known So Far?
Abstract The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized in…
Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches
Abstract The tumour microenvironment (TME) is now recognised as a hallmark of cancer, since tumour:stroma crosstalk supports the key steps…