Dysregulation of the endocannabinoid system – a key factor in the progression of multiple sclerosis?
Abstract The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease…
fatty acid amide hydrolase (FAAH)
Fatty‐acid amide hydrolase inhibition mitigates Alzheimer’s disease progression in mouse models of amyloidosis
Abstract The endocannabinoid N‐arachidonoylethanolamine (AEA) is a pro‐homeostatic bioactive lipid known for its anti‐inflammatory, anti‐oxidative, immunomodulatory, and neuroprotective properties, which…
Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
Abstract Alzheimer’s disease (AD), the most common neurodegenerative disease (NDD), is characterized by chronic neuronal cell death through progressive loss…
Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta
Abstract Plasma concentrations of N-arachidonyletholamine (AEA), N-oleoylethanolamide (OEA) and N-palmitoylethanolamide (PEA) increase at term and can predict when a woman…
Tonic Endocannabinoid Levels Modulate Retinal Signaling
Abstract The endocannabinoid (eCB) system is critically involved in the modulation of synaptic transmission in the central nervous system, playing…
Sex and stressor modality influence acute stress-induced dynamic changes in corticolimbic endocannabinoid levels in adult Sprague Dawley rats
Abstract Research over the past few decades has established a role for the endocannabinoid system in contributing to the neural…
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
Abstract The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants…
Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
Abstract Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools…
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration
Abstract Human immunodeficiency virus type 1 (HIV-1) is known to provoke microglial immune responses which likely play a paramount role…