The endocannabinoid system – current implications for drug development
Abstract In this review, the state of the art for compounds affecting the endocannabinoid (eCB) system is described with a…
fatty acid amide hydrolase (FAAH)
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review
Abstract Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several…
Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer’s disease?
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder which accounts for 60–70% of the 50 million worldwide cases of dementia…
Chinese Herbal Medicine (MaZiRenWan) Improves Bowel Movement in Functional Constipation Through Down-Regulating Oleamide
Abstract In a prospective, randomized, three-arms, controlled clinical study, Chinese Herbal Medicine MaZiRenWan (MZRW, also known as Hemp Seed Pill)…
Endocannabinoid System in the Airways
Abstract Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of…
Acute Administration of URB597 Fatty Acid Amide Hydrolase Inhibitor Prevents Attentional Impairments by Distractors in Adolescent Mice
Abstract The maturation of attentional control during adolescence might influence later functional outcome or predisposition to psychiatric disorders. During adolescence,…
Modulation of the Endocannabinoid System as a Potential Anticancer Strategy
Abstract Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids…
A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)
Abstract This perspective was adapted from a Career Achievement Award talk given at the International Cannabinoid Research Society Symposium in…
Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
Abstract Cannabis and analogs of Δ9-tetrahydrocannabinol have been used for therapeutic purposes, but their therapeutic use remains limited because of…