Bioinformatics analysis identifies AURKB as a prognostic biomarker across multiple human cancers
Abstract Background: Cancer is a major global health issue. Aurora kinase B (AURKB) is known to regulate cell division and…
epigenetic regulation
A pancancer analysis reveals the oncogenic role of glutaminase 1 (GLS1) in tumor metabolism and immune evasion: a bioinformatics analysis
Abstract Background: Metabolic reprogramming is a significant factor that regulates the function and differentiation of immune cells, thereby influencing the…
A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and Immunity
Abstract Introduction: Epigenetic-targeted therapy has been increasingly applied in the treatment of cancers. Lysine (K)-specific demethylase 6B (KDM6B) is an…
GATA binding protein 1 recruits histone deacetylase 2 to the promoter region of nuclear receptor binding protein 2 to affect the tumor microenvironment and malignancy of thyroid carcinoma
Abstract The tumor microenvironment (TME) and activated angiogenesis in thyroid carcinoma (TC) are critical for tumor growth and metastasis. Nuclear…
Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles
Abstract DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis…