Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-80440-z. Article type: Research Article Keywords: Modular lytic enzyme,…
Abstract Background: Clostridium perfringens is a significant cause of food poisoning. Broad-spectrum antibiotics, commonly used to control C. perfringens, are…
Abstract The increasing antibiotic resistance among bacteria challenges the biotech industry to search for new antibacterial molecules. Endolysin TP84_28 is…
Abstract Background/Objectives: The World Health Organization has selected enterococci as one of the priority multidrug-resistant microorganisms for the development of…
Abstract Geobacillus stearothermophilus is a highly thermophilic, spore-forming Gram-positive bacterium that causes flat sour spoilage in low-acid canned foods. To…
Abstract We have structurally and functionally characterized Skl and Pal endolysins, the latter being the first endolysin shown to kill…
Abstract The emergence of multidrug-resistant bacteria has made minor bacterial infections incurable with many existing antibiotics. Lysins are phage-encoded peptidoglycan…
Abstract Endolysins are phage-encoded enzymes implicated in the breaching of the bacterial cell wall at the end of the viral…
Abstract Bacteriophage endolysins, enzymes that degrade the bacterial peptidoglycan (PG), have gained an increasing interest as alternative antimicrobial agents, due…
Abstract Endolysins are bacteriophage-derived enzymes that hydrolyze the peptidoglycan of host bacteria. Endolysins are considered to be promising tools for…