Abstract The endocannabinoid system (ECS) is a primary regulatory system in human physiology that serves to help maintain homeostasis throughout…
Abstract Background: Dysregulated endocannabinoid signaling is involved in Fragile X syndrome (FXS), suggesting a potential role for the endocannabinoid signaling…
Abstract Modern biomedicine frequently contextualizes disease around isolated molecular or organ-specific mechanisms, but numerous chronic diseases, including Alzheimer’s disease, multiple…
Abstract Epilepsy is characterized by the predisposition to epileptic seizures resulting from neuronal hyperexcitability and hypersynchrony. Seizure management consists primarily…
Abstract Neuropathic pain is a clinically challenging syndrome that is largely refractory to conventional therapies. It arises from lesions or…
Abstract As a psychoactive drug, marijuana is used for recreational purposes. Given its addictive nature and the serious damage it…
Abstract Background: Chronic inflammatory skin disorders, including atopic dermatitis, psoriasis, acne, and chronic wounds, affect nearly two billion people worldwide,…
Abstract Background: Alcohol‐associated liver disease (ALD) is a leading cause of liver‐related morbidity and mortality, yet effective therapeutic options remain…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12964-025-02418-2. Article type: Research Article Keywords: Amyotrophic lateral sclerosis,…
Abstract Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases, often leading to strictures that require endoscopic…