High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells
Abstract Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and is one of the most…
endocannabinoid system
Unraveling the Intoxicating and Therapeutic Effects of Cannabis Ingredients on Psychosis and Cognition
Abstract Research evidence suggests a dose–response relationship for the association between cannabis use and risk of psychosis. Such relationship seems…
The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders
Abstract BACKGROUND: The endocannabinoid system (ECS) consists of the cannabinoid receptors CB1 and CB2, the main endocannabinoids anandamide (AEA) and…
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
Abstract The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision. Therefore, the search of biomarkers is…
A Guide to Targeting the Endocannabinoid System in Drug Design
Abstract The endocannabinoid system (ECS) is one of the most crucial systems in the human organism, exhibiting multi-purpose regulatory character.…
The Epigenetics of the Endocannabinoid System
Abstract The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and…
Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
Abstract Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the…
Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?
Abstract γ-Aminobutyric acid type A receptors (GABAARs) are the main inhibitory mediators in the central nervous system (CNS). GABAARs are…
The endocrine disruptor DEHP and the ECS: analysis of a possible crosstalk
Abstract Studies of the last decade associated the environmental contamination by di-(2-ethylhexyl)-phthalate (DEHP) with obesity and endocrine malfunction. DEHP was…
Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells
Abstract Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and…