A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
Abstract Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest…
endocannabinoid system
Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
Abstract The plant Cannabis sativa contains cannabinoids represented by Δ9-tetrahydrocannabinol, which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2…
Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis
Abstract Recent findings highlight the emerging role of the endocannabinoid system in the control of symptoms and disease progression in…
Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials
Abstract Post-traumatic stress disorder (PTSD) is characterized by poor adaptation to a traumatic experience. This disorder affects approximately 10% of…
Therapeutic potential of medicinal marijuana: an educational primer for health care professionals
Abstract With the proposed Canadian July 2018 legalization of marijuana through the Cannabis Act, a thorough critical analysis of the…
The Role of Cannabinoids in the Setting of Cirrhosis
Abstract Although the mortality rates of cirrhosis are underestimated, its socioeconomic burden has demonstrated a significant global impact. Cirrhosis is…
Mechanistic Potential and Therapeutic Implications of Cannabinoids in Nonalcoholic Fatty Liver Disease
Abstract Nonalcoholic fatty liver disease (NAFLD) is comprised of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). It is defined…
Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter
Abstract Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and…
Review of the neurological benefits of phytocannabinoids
Abstract Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600…
The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders
Abstract Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The…