Cannabidiol (CBD) in Cancer Management
Abstract Simple Summary: Cannabidiol (CBD) is one of the main constituents of the plant Cannabis sativa. Surveys suggest that medicinal…
endocannabinoid system
The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation
Abstract Microglia, the resident immune cells of the brain, can take on a range of pro- or anti-inflammatory phenotypes to…
Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
Abstract Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools…
The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
Abstract Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist…
The Mediterranean Diet as a Source of Bioactive Molecules with Cannabinomimetic Activity in Prevention and Therapy Strategy
Abstract The endocannabinoid system is a complex lipid signaling network that has evolved to be a key regulator of pro-homeostatic…
New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in CNS Disorders
Abstract The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in the regulation of mental health. Consequently,…
Cannabinoids for the Treatment of Dermatologic Conditions
Abstract In recent years, cannabinoid (CB) products have gained popularity among the public. The anti-inflammatory properties of CBs have piqued…
Enhancing Endocannabinoid Control of Stress with Cannabidiol
Abstract The stress response is a well-defined physiological function activated frequently by life events. However, sometimes the stress response can…
The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models
Abstract Epilepsy is one of the most common neurological conditions. Yearly, five million people are diagnosed with epileptic-related disorders. The…
Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Abstract Major depressive disorder is a high-impact, debilitating disease and it is currently considered the most prevalent mental illness. It…