Cannabinoids and Multiple Sclerosis: A Critical Analysis of Therapeutic Potentials and Safety Concerns
Abstract Multiple sclerosis (MS) is a complicated condition in which the immune system attacks myelinated axons in the central nervous…
endocannabinoid system
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Abstract Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20%…
Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation
Abstract Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)-“endocannabinoidome”, consists of the endogenous ligands, eCBs, their canonical and non-canonical receptor…
Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer’s disease: A systematic review and meta-analysis of animal studies
Abstract Objective: Over the last decade, researchers have sought to develop novel medications against dementia. One potential agent under investigation…
Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats
Abstract The pathophysiology of major depressive disorder (MDD) is diverse and multi-factorial, yet treatment strategies remain limited. While women are…
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review
Abstract Background: There is a growing liberalization of cannabis-based preparations for medical and recreational use. In multiple instances, anxiety and…
The use of cannabidiol as a novel treatment for oral stereotypic behaviour (crib-biting) in a horse
Abstract This case describes a chronic crib-biting /wind suking horse. Severe long-term consequences of a behavior disorder in the patient…
Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective
Abstract The endocannabinoid system (ECS) plays a very important role in numerous physiological and pharmacological processes, such as those related…
Role of the Endocannabinoid System in Metabolic Control Processes and in the Pathogenesis of Metabolic Syndrome: An Update
Abstract Metabolic syndrome is a complex disease state, which appears mostly as a consequence of an unhealthy, sedentary lifestyle. Metabolic…
Endocannabinoid System: Chemical Characteristics and Biological Activity
Abstract The endocannabinoid system (eCB) has been studied to identify the molecular structures present in Cannabis sativa. eCB consists of…